Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653937 | 0.86 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL84424 | 0.83 | CA1 (0.59) | CA1CA2CA12CA9CA14 | |
| SCHEMBL4333209 | 0.82 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL10610953 | 0.82 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL28599280 | 0.82 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL13876418 | 0.82 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL1516780 | 0.82 | CA1 (0.57) | CA1CA2CA12CA9CA14 | |
| SCHEMBL4640174 | 0.81 | CA1 (0.61) | CA1CA2CA12CA9CA14 | |
| SCHEMBL21147155 | 0.81 | CA1 (0.52) | CA1CA2CA12CA9CA14 | |
| SCHEMBL8759811 | 0.80 | CA1 (0.55) | CA1CA2CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-18 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
| US-8227492-B2 | Sulfoxamine derivatives as factor Xa inhibitors | CADILA HEALTHCARE LIMITED (IN) | 2012-07-24 | — | — | US | disclosed |
| US-20110065717-A1 | SULFOXIMINE DERIVATIVES AS FACTOR XA INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | PHGDH, PGD, PGK1 | CA1 445/4885CA2 264/4885CA12 1176/4885 |
| US-20110065717-A1 | SULFOXIMINE DERIVATIVES AS FACTOR XA INHIBITORS | TFPI, F12, F2 | CA1 2870/4885CA2 3550/4885CA12 2461/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | CA1 453/4885CA2 261/4885CA12 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.