SCHEMBL6521767

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)Oc1ccc2c(c1)Oc1cc(O)ccc1C21OC(=O)c2ccccc21)NC(=O)[C@H](C)NC(=O)COCCOCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O)C(C)C)C(C)C)C(C)C

nearest known ligand 0.57

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	GLP1R	P43220	12/20	0.57

▸	GCGR	P47871	9/20	0.57

▸	GIPR	P48546	6/20	0.53

▸	RAMP3	O60896	2/20	0.53

▸	CALCR	P30988	2/20	0.53

▸	CCKBR	P32239	2/20	0.52

▸	PRMT5	O14744	2/20	0.52

▸	WDR77	Q9BQA1	2/20	0.52

▸	APLNR	P35414	1/20	0.52

▸	TFPI	P10646	2/20	0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Biotin SCHEMBL6521802	0.83	GLP1R (0.59)	GLP1RGCGRGIPRRAMP3CALCR
SCHEMBL31182477	0.76	APLNR (0.64)	APLNRTFPI
SCHEMBL31182958	0.76	GLP1R (0.66)	GLP1RGCGRGIPRRAMP3CALCR
SCHEMBL30511759	0.76	CALCR (0.66)	GLP1RGCGRCALCRTFPI
SCHEMBL30818417	0.76	TFPI (0.68)	RAMP3CALCRTFPI
SCHEMBL30262200	0.75	GLP1R (0.60)	GLP1RGCGRGIPRCALCRAPLNR
SCHEMBL30262218	0.75	C5AR1 (0.59)	GLP1RGCGRGIPRRAMP3CALCR
SCHEMBL29783631	0.75	CALCR (0.73)	GLP1RRAMP3CALCRCCKBRTFPI
SCHEMBL30818412	0.75	CALCR (0.69)	GLP1RGCGRRAMP3CALCRTFPI
SCHEMBL30818413	0.75	CALCR (0.69)	GLP1RGCGRRAMP3CALCRTFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20050118598-A1	Organic compounds	GARCIA-ECHEVERRIA CARLOS (CH)	2005-06-02	—	—	US	disclosed
EP-1478665-A2	ORGANIC COMPOUNDS HAVING ANTI-ANGIOGENIC ACTIVITY	Novartis AG (CH)	2004-11-24	—	—	EP	disclosed
WO-2003070769-A2	ORGANIC COMPOUNDS HAVING ANTI-ANGIOGENIC ACTIVITY	NOVARTIS AG (CH)	2003-08-28	—	—	WO	disclosed