SCHEMBL6522547

SCHEMBL6522547

CNc1ccc(Oc2ccc(NC)c([N+](=O)[O-])c2)cc1[N+](=O)[O-]

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.57
HTT P42858 2/20 0.54
CDC25B P30305 1/20 0.48
MAPT P10636 4/20 0.47
MAPK1 P28482 4/20 0.47
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 4/20 0.47
TDP1 Q9NUW8 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
AKR1C3 P42330 2/20 0.46
AKR1C2 P52895 2/20 0.46
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
ALDH3A1 P30838 1/20 0.45
POLB P06746 1/20 0.44
RECQL P46063 1/20 0.44
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5350139 0.92 MEN1 (0.52) HCAR3HTTMAPTMAPK1RAB9A
SCHEMBL430629 0.88 MAPT (0.59) HCAR3MAPTMAPK1RAB9ASMN1; SMN2
SCHEMBL13559522 0.86 HCAR3 (0.45) HCAR3HTTCDC25BMAPTMAPK1
SCHEMBL13211382 0.86 MAPT (0.53) HCAR3HTTMAPTMAPK1SMN1; SMN2
SCHEMBL4326964 0.85 HCAR3 (0.44) HCAR3HTTCDC25BMAPTMAPK1
SCHEMBL27734810 0.84 ALDH1A1 (0.44) HCAR3HTTMAPTMAPK1RAB9A
SCHEMBL12706983 0.83 HCAR3 (0.51) HCAR3HTTCDC25BMAPTMAPK1
SCHEMBL1435159 0.83 HCAR3 (0.42) HCAR3HTTCDC25BMAPTMAPK1
SCHEMBL1435396 0.83 MAPT (0.44) HCAR3HTTCDC25BMAPTMAPK1
SCHEMBL117243 0.82 HCAR3 (0.50) HCAR3HTTCDC25BMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1179028-B1 SOLVENT RESISTANT PHOTOSENSITIVE COMPOSITIONS SYNTRIX BIOCHIP INC (US) 2005-03-02 EP claimed
US-6569598-B2 Photoresist films comprising aromatic polyamides that are stable and impervious to solvents used as barrier layers for preferential solid-phase synthesis with micron-scale resolution SYNTRIX BIOCHIP, INC. 2003-05-27 US claimed
US-20030064316-A1 Solvent resistant photosensitive compositions US ARMY, SECRETARY OF THE ARMY 2003-04-03 US claimed
JP-2002531470-A 2002-09-24 JP claimed
EP-1163374-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES Syntrix Biochip, Inc. (US) 2001-12-19 EP claimed
WO-2000033084-A2 ARRAYS OF ORGANIC COMPOUNDS ATTACHED TO SURFACES SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO claimed
US-6951682-B1 Porous coatings bearing ligand arrays and use thereof SYNTRIX BIOCHIP, INC. (US) 2005-10-04 US disclosed
EP-1179028-B1 SOLVENT RESISTANT PHOTOSENSITIVE COMPOSITIONS SYNTRIX BIOCHIP INC (US) 2005-03-02 EP disclosed
US-6569598-B2 Photoresist films comprising aromatic polyamides that are stable and impervious to solvents used as barrier layers for preferential solid-phase synthesis with micron-scale resolution SYNTRIX BIOCHIP, INC. 2003-05-27 US disclosed
US-20030064316-A1 Solvent resistant photosensitive compositions US ARMY, SECRETARY OF THE ARMY 2003-04-03 US disclosed
EP-1179028-A1 SOLVENT RESISTANT PHOTOSENSITIVE COMPOSITIONS Syntrix Biochip, Inc. (US) 2002-02-13 EP disclosed
EP-1163520-A1 POROUS COATINGS BEARING LIGAND ARRAYS Syntrix Biochip, Inc. (US) 2001-12-19 EP disclosed
US-6159681-A Light-mediated method and apparatus for the regional analysis of biologic material SYNTRIX BIOCHIP, INC. (US) 2000-12-12 US disclosed
WO-2000032678-A1 SOLVENT RESISTANT PHOTOSENSITIVE COMPOSITIONS SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO disclosed
WO-2000033078-A1 POROUS COATINGS BEARING LIGAND ARRAYS SYNTRIX BIOCHIP, INC. (US) 2000-06-08 WO disclosed
WO-1999061653-A2 LIGHT-MEDIATED REGIONAL ANALYSIS OF BIOLOGIC MATERIAL SYNTRIX BIOCHIP (US) 1999-12-02 WO disclosed