SCHEMBL6522909

SCHEMBL6522909

CC(O)c1nc2cc([N+](=O)[O-])ccc2[nH]1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.62
KMT2A Q03164 5/20 0.62
POLB P06746 3/20 0.62
USP2 O75604 1/20 0.62
ALDH1A1 P00352 5/20 0.50
CYP1A2 P05177 2/20 0.49
MAPT P10636 6/20 0.47
ALOX15 P16050 1/20 0.47
RIPK1 Q13546 1/20 0.45
NPBWR1 P48145 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
MAOB P27338 1/20 0.43
NOS1 P29475 1/20 0.43
HTT P42858 3/20 0.43
KDM4E B2RXH2 1/20 0.43
GRIA1 P42261 1/20 0.43
GRIA2 P42262 1/20 0.43
GRIA3 P42263 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6519411 1.00 MEN1 (0.62) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL271676 0.88 MEN1 (0.57) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL5104056 0.86 MEN1 (0.55) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL10752982 0.86 MEN1 (0.55) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL5213709 0.82 POLB (0.57) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL27415790 0.82 KMT2A (0.51) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL28378483 0.80 MEN1 (0.51) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL14770512 0.79 MEN1 (0.51) MEN1KMT2APOLBUSP2ALDH1A1
SCHEMBL4328210 0.79 ALDH1A1 (0.58) MEN1KMT2APOLBALDH1A1MAPT
SCHEMBL2711226 0.79 ALDH1A1 (0.58) MEN1KMT2APOLBUSP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9323153-B2 Actinic ray-sensitive or radiation-sensitive resin composition, and, actinic ray-sensitive or radiation-sensitive film and pattern forming method, each using the same FUJIFILM CORPORATION (JP) 2016-04-26 US disclosed
US-9323153-B2 Actinic ray-sensitive or radiation-sensitive resin composition, and, actinic ray-sensitive or radiation-sensitive film and pattern forming method, each using the same FUJIFILM CORPORATION (JP) 2016-04-26 US disclosed
US-20150004533-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM AND PATTERN FORMING METHOD, EACH USING THE SAME FUJIFILM CORPORATION (JP) 2015-01-01 US disclosed
US-20150004533-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM AND PATTERN FORMING METHOD, EACH USING THE SAME FUJIFILM CORPORATION (JP) 2015-01-01 US disclosed
WO-2013147286-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM AND PATTERN FORMING METHOD, EACH USING THE SAME FUJIFILM CORPORATION (JP) 2013-10-03 WO disclosed
US-20050148643-A1 Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme AGOURON PHARMACEUTICALS, INC. 2005-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148643-A1 Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme CHEK1, CHEK2, RAD1 MEN1 1178/4885KMT2A 860/4885POLB 177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.