Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136901 | 0.92 | C5AR1 (0.46) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL5136579 | 0.89 | C5AR1 (0.44) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL5135363 | 0.89 | C5AR1 (0.44) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL1912970 | 0.88 | C5AR1 (0.40) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL5137466 | 0.87 | DHFR (0.42) | C5AR1TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5137404 | 0.86 | CRHR1 (0.43) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL651500 | 0.85 | C5AR1 (0.43) | C5AR1TSHRKDM4EALDH1A1MDM2 | |
| SCHEMBL5136475 | 0.84 | C5AR1 (0.46) | C5AR1TSHRKDM4EALDH1A1CASR | |
| SCHEMBL649659 | 0.84 | CASR (0.46) | C5AR1TSHRKDM4EALDH1A1CASR | |
| SCHEMBL5137538 | 0.84 | C5AR1 (0.46) | C5AR1TSHRKDM4EALDH1A1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |