Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029702 | 0.88 | ALDH1A1 (0.67) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL991486 | 0.83 | MAPT (0.61) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL7575984 | 0.83 | MAPT (0.60) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL6037012 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL18009919 | 0.81 | MAPT (0.66) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL284851 | 0.80 | MAPT (0.65) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL5445148 | 0.80 | MEN1 (0.68) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL23029210 | 0.79 | MEN1 (0.70) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL4961814 | 0.79 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL3248111 | 0.78 | GSTP1 (0.67) | MAPTALDH1A1MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050208037-A1 | Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2005-09-22 | — | — | US | disclosed |