Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 2/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6515042 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL6517936 | 0.77 | — | — | |
| SCHEMBL1941203 | 0.71 | GPR3 (0.38) | GPR3PBRM1TNKS2 | |
| Hydrochloric Acid SCHEMBL6352940 | 0.71 | GPR3 (0.34) | GPR3 | |
| Ethylene SCHEMBL10454711 | 0.71 | GPR3 (0.34) | GPR3 | |
| Hydrochloric Acid SCHEMBL29097443 | 0.71 | GPR3 (0.34) | GPR3 | |
| Hydrochloric Acid SCHEMBL31318024 | 0.69 | GPR3 (0.33) | GPR3 | |
| SCHEMBL17008820 | 0.68 | GPR3 (0.35) | GPR3PBRM1TNKS2 | |
| SCHEMBL6345077 | 0.68 | GPR3 (0.35) | GPR3PBRM1TNKS2 | |
| SCHEMBL6757894 | 0.68 | AURKA (0.38) | GPR3PBRM1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872863-B2 | Methylene bridged metallocenes as olefin-polymerization catalyst components | BASELL POLYOLEFINE GMBH (DE) | 2005-03-29 | — | — | US | disclosed |
| US-20040147695-A1 | Methylene bridged metallocenes as olefin-polymerization catalyst components | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-07-29 | — | — | US | disclosed |
| US-6693156-B1 | SIMPLY AND EFFICIENTLY SYNTHESIZED MATERIALS WITH VARIED SUBSTITUTION FOR TAILORED POLYMER PROPERTIES | BASELL POLYOLEFINE GMBH (DE) | 2004-02-17 | — | — | US | disclosed |
| EP-1131328-B1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | BASELL POLYOLEFINE GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| EP-1131328-A1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | Basell Technology Company B.V. (NL) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029415-A1 | METHYLENE BRIDGED METALLOCENES AS OLEFIN-POLYMERIZATION-CATALYST COMPONENTS | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2000-05-25 | — | — | WO | disclosed |