Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL7115101 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL20338904 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL28328411 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL28393262 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL115545 | 0.97 | — | — | |
| Ether SCHEMBL17766472 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL7763625 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL9317524 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL5597101 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TSHRFFAR3LCKFYN | |
| Ether SCHEMBL11311472 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TSHRFFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050089504-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2005-04-28 | — | — | US | disclosed |
| EP-1076262-B1 | Photosensitive resin | MITSUBISHI GAS CHEMICAL CO (JP) | 2004-10-20 | — | — | EP | disclosed |
| US-6680152-B2 | CURABLE MIXTURE OF THE REACTION PRODUCT OF AN EPOXY ACRYLATE WITH A CYANATE ESTER AND A POLYBASIC ACID ANHYDRIDE, AND A COMPOUND OR POLYMER OF (POLY)PROPYLENE GLYCOL AND TOLUENE DIISOCYANATE, ESTERIFIED WITH 2-HYDROXYETHYL ACRYLATE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2004-01-20 | — | — | US | disclosed |
| US-20030170202-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-09-11 | — | — | US | disclosed |
| US-6524769-B1 | Heat resistance and reliability on electric insulation under moisture; printed circuit; difunctional epoxy acrylate with biphenyl skeleton with a cyanate ester compound and a polybasic acid anhydride | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2003-02-25 | — | — | US | disclosed |
| US-20030017414-A1 | Photosensitive resin composition | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2003-01-23 | — | — | US | disclosed |
| US-6497895-B2 | TRANSDERMAL PATCH | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-12-24 | — | — | US | disclosed |
| US-20020035217-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-03-21 | — | — | US | disclosed |
| US-6328988-B1 | DRUGS AND COSMETICS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2001-12-11 | — | — | US | disclosed |
| EP-1076262-A1 | Photosensitive resin | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-4736058-A | ANTICOAGULANTS, VASODILATORS | TEIJIN LIMITED (JP) | 1988-04-05 | — | — | US | disclosed |
| US-4140779-A | ANTIDEPRESSANTS | AYERST, MCKENNA AND HARRISON LIMITED (CA) | 1979-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089504-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | LIPA, ABHD16A, CHMP4B | ALDH1A1 4146/4885TSHR 4158/4885FFAR3 642/4885 |
| US-20030170202-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | LIPA, ABHD16A, CHMP4B | ALDH1A1 4146/4885TSHR 4158/4885FFAR3 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.