Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113401 | 0.88 | GPR119 (0.47) | GPR119USP30LIPEFPR2 | |
| SCHEMBL4113397 | 0.88 | GPR119 (0.47) | GPR119USP30LIPEFPR2 | |
| SCHEMBL650730 | 0.85 | GPR119 (0.49) | GPR119USP30 | |
| SCHEMBL653926 | 0.85 | GPR119 (0.49) | GPR119USP30 | |
| SCHEMBL651844 | 0.83 | GPR119 (0.66) | GPR119USP30LIPE | |
| SCHEMBL654092 | 0.83 | GPR119 (0.66) | GPR119USP30LIPE | |
| SCHEMBL653668 | 0.82 | GPR119 (0.46) | GPR119NR1H2 | |
| SCHEMBL653669 | 0.82 | GPR119 (0.46) | GPR119NR1H2 | |
| SCHEMBL650659 | 0.82 | JAK2 (0.48) | GPR119 | |
| SCHEMBL2064484 | 0.82 | JAK2 (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |