Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653926 | 1.00 | GPR119 (0.49) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL652005 | 0.93 | CHRNB2 (0.52) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL650042 | 0.93 | CHRNB2 (0.52) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL651995 | 0.92 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL653364 | 0.92 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18452908 | 0.86 | HRH3 (0.48) | GPR119USP30 | |
| SCHEMBL652471 | 0.85 | GPR119 (0.47) | GPR119USP30 | |
| SCHEMBL4113401 | 0.84 | GPR119 (0.47) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4113397 | 0.84 | GPR119 (0.47) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3579682 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |