Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.52 |
| ▸ | ACP3 | P15309 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19753552 | 0.86 | MME (0.55) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL15384059 | 0.86 | MME (0.55) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL17161710 | 0.86 | MEN1 (0.53) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL5079891 | 0.85 | MEN1 (0.51) | MEN1KMT2AAPAF1ACP3SIGMAR1 | |
| SCHEMBL9752562 | 0.84 | APAF1 (0.56) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL17530041 | 0.84 | MMP9 (0.55) | APAF1MMEPOLBCTDSP1 | |
| SCHEMBL7620487 | 0.84 | APAF1 (0.56) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL11774297 | 0.84 | APAF1 (0.51) | MEN1KMT2AAPAF1ACP3SIGMAR1 | |
| SCHEMBL7944349 | 0.84 | APAF1 (0.56) | MEN1KMT2AAPAF1MMEACP3 | |
| SCHEMBL18722285 | 0.84 | MMP9 (0.55) | APAF1MMEPOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| US-7872010-B2 | Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |