Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 0.62 |
| ▸ | HTR1D | P28221 | 15/20 | 0.62 |
| ▸ | HTR1B | P28222 | 15/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172034 | 0.98 | HTR1A (0.64) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4189338 | 0.96 | HTR1A (0.66) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4174687 | 0.85 | HTR1A (0.61) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4172085 | 0.82 | HTR1A (0.53) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL532984 | 0.79 | HTR1A (0.63) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL14510673 | 0.78 | HTR1A (0.62) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL10864650 | 0.78 | DRD2 (0.74) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL2358961 | 0.77 | HTR1A (0.73) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4189187 | 0.77 | HTR1A (1.00) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4182140 | 0.77 | HTR1A (0.72) | HTR1AHTR1DHTR1BSLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562917-A1 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-08-17 | — | — | EP | claimed |
| WO-2004046124-A1 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-06-03 | — | — | WO | claimed |