Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cirazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 5/20 | 0.70 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 0.70 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.70 |
| ▸ | NISCH | Q9Y2I1 | 10/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.70 |
| ▸ | HTR1A | P08908 | 5/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | THPO | P40225 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cirazoline SCHEMBL6558088 | 0.86 | NISCH (0.52) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Cirazoline SCHEMBL29430417 | 0.84 | NISCH (1.00) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Cirazoline SCHEMBL126496 | 0.84 | NISCH (1.00) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Cirazoline SCHEMBL3176595 | 0.82 | LMNA (1.00) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Cirazoline SCHEMBL466850 | 0.82 | LMNA (1.00) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Lofexidine SCHEMBL3670274 | 0.77 | ADRA2A (0.65) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL3169242 | 0.75 | NISCH (0.68) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Hydrochloric Acid SCHEMBL9652303 | 0.74 | LMNA (0.77) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| Clonidine SCHEMBL2874999 | 0.74 | TAAR1 (0.62) | NISCHADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL3170348 | 0.73 | NISCH (0.62) | NISCHADRA1AADRA1DADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050232860-A1 | Use of edg-receptor agonists for the treatment of hypertension | SOLVAY PHARMACEUTICALS GMBH (DE) | 2005-10-20 | — | — | US | disclosed |