Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030890 | 0.77 | TDP1 (0.49) | TDP1KMT2AGAALMNAKDM4E | |
| SCHEMBL9598307 | 0.77 | TDP1 (0.49) | TDP1RAB9AKMT2AGAANPC1 | |
| SCHEMBL9598311 | 0.77 | TDP1 (0.57) | TDP1RAB9AKMT2AGAANPC1 | |
| SCHEMBL5096967 | 0.77 | RAD52 (0.54) | TDP1RAB9AKMT2AGAALMNA | |
| SCHEMBL6526403 | 0.77 | SMN1; SMN2 (0.43) | TDP1RAB9AKMT2AGAANPC1 | |
| SCHEMBL4791596 | 0.76 | POLB (0.62) | TDP1RAB9AKMT2AGAANPC1 | |
| Hydrochloric Acid SCHEMBL522539 | 0.76 | RAD52 (0.53) | TDP1RAB9AKMT2AGAALMNA | |
| SCHEMBL6525820 | 0.75 | ALDH1A1 (0.42) | TDP1RAB9AKMT2AGAANPC1 | |
| SCHEMBL485294 | 0.75 | TDP1 (0.53) | TDP1RAB9AKMT2AGAANPC1 | |
| SCHEMBL9198468 | 0.75 | KMT2A (0.49) | TDP1KMT2AGAAMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575925-A1 | NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004056784-A1 | NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-08 | — | — | WO | disclosed |