Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14689917 | 0.83 | PTGS1 (0.63) | CYSLTR2CYSLTR1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL10294657 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1PKMHPGD | |
| SCHEMBL7529670 | 0.81 | PTPN1 (0.67) | SMN1; SMN2LMNAALDH1A1CA2PTPN1 | |
| SCHEMBL30872951 | 0.79 | LMNA (0.60) | SMN1; SMN2LMNAALDH1A1PKMHPGD | |
| SCHEMBL27182624 | 0.79 | LMNA (0.60) | SMN1; SMN2LMNAALDH1A1PKMHPGD | |
| SCHEMBL6000980 | 0.79 | PTPN1 (0.63) | CYSLTR2CYSLTR1ALDH1A1CA2PTPN1 | |
| SCHEMBL6086574 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1PKMHPGD | |
| SCHEMBL19567186 | 0.77 | PTGS1 (0.63) | SMN1; SMN2PKMCA2PTGS1PTGS2 | |
| Cyanide SCHEMBL28184916 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1PKMHPGD | |
| SCHEMBL691809 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930131-B2 | Aryl substituted 3-ethoxy phenyl trifluoromethane sulfonamides for the treatment of non-insulin dependent diabetes mellitus (NIDDM) | WYETH (US) | 2005-08-16 | — | — | US | disclosed |