Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 8/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669494 | 0.72 | NR1H2 (0.55) | NR1H3NR1H2LMNAPDK2ADORA2A | |
| SCHEMBL1899895 | 0.70 | NR1H2 (0.58) | NR1H3NR1H2LMNAADORA2ANPC1 | |
| SCHEMBL2225445 | 0.69 | NR1H2 (0.47) | NR1H3NR1H2LMNAPDK2ADORA2A | |
| SCHEMBL11642290 | 0.69 | NR1H2 (0.55) | NR1H3NR1H2LMNAPDK2ADORA2A | |
| SCHEMBL28718402 | 0.68 | SIGMAR1 (0.47) | SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9166001 | 0.68 | XDH (0.50) | NR1H3NR1H2LMNANPC1RAB9A | |
| SCHEMBL3422456 | 0.67 | SIGMAR1 (0.46) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11643873 | 0.67 | SIGMAR1 (0.46) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3809940 | 0.67 | SIGMAR1 (0.46) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27428862 | 0.66 | NR1H2 (0.61) | NR1H3NR1H2LMNAADORA2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171423-B1 | CARBAMIC ACID DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2005-01-12 | — | — | EP | disclosed |