Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532637 | 0.80 | PIK3CA (0.47) | GRM4 | |
| SCHEMBL6526545 | 0.77 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL6532215 | 0.77 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL2925598 | 0.74 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL2925618 | 0.69 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CEGFR | |
| SCHEMBL2926129 | 0.67 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL6070039 | 0.66 | GRM4 (0.38) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL2930478 | 0.65 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL1157276 | 0.65 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL21947547 | 0.65 | MAPT (0.60) | MAPTHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | claimed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | claimed |