Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.43 |
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526545 | 0.89 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CRORC | |
| SCHEMBL6527184 | 0.86 | PTGS2 (0.42) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL6532108 | 0.83 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6528413 | 0.82 | PIK3CA (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6469174 | 0.81 | PTGS2 (0.52) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL6529700 | 0.81 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6532820 | 0.81 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2925618 | 0.81 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL2925598 | 0.78 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CGRM4 | |
| SCHEMBL6468561 | 0.77 | GAA (0.40) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |