Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Mexiletine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A known ✓ | P35499 | 10/20 | 0.67 |
| ▸ | SCN5A known ✓ | Q14524 | 3/20 | 0.67 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.67 |
| ▸ | SCN9A known ✓ | Q15858 | 2/20 | 0.67 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 0.67 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.67 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.67 |
| ▸ | SCN11A known ✓ | Q9UI33 | 1/20 | 0.67 |
| ▸ | SCN8A known ✓ | Q9UQD0 | 1/20 | 0.67 |
| ▸ | SCN10A known ✓ | Q9Y5Y9 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mexiletine SCHEMBL2720309 | 0.89 | SCN4A (0.67) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL2717942 | 0.85 | SCN4A (0.75) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL6518643 | 0.85 | SCN4A (0.80) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL8819167 | 0.82 | SCN4A (0.80) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| (S)-Mexiletine SCHEMBL13046569 | 0.82 | SCN4A (1.00) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL16081 | 0.82 | SCN4A (1.00) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| (R)-Mexiletine SCHEMBL16082 | 0.82 | SCN4A (1.00) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL8858385 | 0.82 | SCN4A (1.00) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL11705435 | 0.81 | SCN4A (0.73) | SCN4ASCN5ACYP2D6LMNASCN1A | |
| Mexiletine SCHEMBL6518638 | 0.80 | SCN4A (0.71) | SCN4ASCN5ACYP2D6LMNASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | SHIRE LLC | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028552-A1 | MEXILETINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF | VIP, TRPV1, LNPEP | SCN4A 131/4885SCN5A 298/4885SCN1A 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.