Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.48 |
| ▸ | PDE4A | P27815 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528128 | 0.90 | ALDH1A1 (0.41) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL2927444 | 0.85 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL6466878 | 0.85 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL1157901 | 0.84 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL2924647 | 0.81 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL1157552 | 0.80 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL6527339 | 0.78 | PDE4A (0.47) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6530112 | 0.75 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2930572 | 0.74 | ALDH1A1 (0.41) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1157804 | 0.73 | FGFR3 (0.42) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |