Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586077 | 0.96 | JAK2 (0.55) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1586076 | 0.96 | JAK2 (0.55) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30923126 | 0.94 | JAK2 (0.53) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18452966 | 0.94 | JAK2 (0.53) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3058464 | 0.91 | CCR5 (0.51) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31288285 | 0.90 | JAK2 (0.54) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1991997 | 0.90 | JAK2 (0.54) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7689008 | 0.90 | PARP1 (0.49) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL652371 | 0.90 | PARP1 (0.49) | JAK2JAK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8569488 | 0.87 | CCR5 (0.53) | JAK2JAK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |