SCHEMBL6528158

SCHEMBL6528158

COC(=S)NCc1cn(-c2ccc(N3CCN(C(=N)SC)CC3)c(F)c2)nn1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.38
SIRT1 Q96EB6 1/20 0.38
MIF P14174 3/20 0.37
RXRA P19793 12/20 0.37
GRIN1 Q05586 12/20 0.37
GRIN2B Q13224 12/20 0.37
DRD2 P14416 1/20 0.35
DRD3 P35462 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6530137 0.89 KDM1A (0.34) NOTUMSIRT1MIFRXRAGRIN1
SCHEMBL6528013 0.86 NOTUM (0.46) NOTUMMIFCA1CA2CA4
SCHEMBL6532001 0.85 F10 (0.43) NOTUMMIFCA1CA2CA4
SCHEMBL6527037 0.84 NOTUM (0.41) NOTUMSIRT1MIFCA1CA2
SCHEMBL5625779 0.84 NOTUM (0.43) NOTUMMIFRXRAGRIN1GRIN2B
SCHEMBL5624221 0.84 MAOA (0.43) NOTUMMIFRXRAGRIN1GRIN2B
SCHEMBL6531150 0.84 NOTUM (0.42) NOTUMSIRT1MIFRXRAGRIN1
SCHEMBL6527596 0.84 NOTUM (0.42) NOTUMMIFRXRAGRIN1GRIN2B
SCHEMBL14527055 0.83 NOTUM (0.40) NOTUMMIFRXRAGRIN1GRIN2B
SCHEMBL6530200 0.83 NOTUM (0.41) NOTUMMIFRXRAGRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082892-A2 TRIAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2005-09-09 WO disclosed