Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532108 | 0.93 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6527184 | 0.91 | PTGS2 (0.42) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL6529700 | 0.88 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2931748 | 0.87 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL6532215 | 0.82 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2926103 | 0.81 | PDE4D (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2924650 | 0.78 | PTGS2 (0.47) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL2925618 | 0.76 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL6532637 | 0.76 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL6469431 | 0.75 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |