Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.49 |
| ▸ | BCR | P11274 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.45 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529343 | 0.95 | ABL1 (0.50) | ABL1BCRROCK2L3MBTL1NPC1 | |
| SCHEMBL6528938 | 0.81 | ROCK2 (0.51) | KDM4EPOLBMAPTMAPK1ROCK2 | |
| SCHEMBL5415090 | 0.79 | HPGD (0.58) | KDM4EPOLBROCK2L3MBTL1TET3 | |
| SCHEMBL6531053 | 0.79 | ROCK2 (0.46) | MAPK1ROCK2MEN1KMT2ACYP1A2 | |
| SCHEMBL6531731 | 0.76 | TNIK (0.49) | ROCK2 | |
| SCHEMBL16962336 | 0.75 | MKNK1 (0.53) | ABL1NR4A1ROCK2RPS6KB1 | |
| SCHEMBL6531853 | 0.75 | ABL1 (0.55) | ABL1BCRROCK2 | |
| SCHEMBL15473148 | 0.74 | HPGD (0.52) | ABL1BCRKDM4EPOLBMAPT | |
| SCHEMBL6530951 | 0.74 | MKNK1 (0.51) | ROCK2 | |
| SCHEMBL1013494 | 0.74 | ABL1 (0.60) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005103036-A1 | PYRIMIDIN-4-YL-1H-INDAZOL-5YL-AMINES AS CHK1 KINASES INHIBITORS | BIOFOCUS DISCOVERY LTD (GB) | 2005-11-03 | — | — | WO | claimed |