Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531231 | 0.89 | ROCK2 (0.47) | ROCK2MKNK1ROCK1MAPKAPK2ADORA2A | |
| SCHEMBL6531731 | 0.86 | TNIK (0.49) | ROCK2MKNK1MAPKAPK2TNIKCDC7 | |
| SCHEMBL6530951 | 0.86 | MKNK1 (0.51) | ROCK2MKNK1MAPKAPK2TNIKCDC7 | |
| SCHEMBL6530116 | 0.85 | TNIK (0.46) | ROCK2MKNK1ROCK1MAPKAPK2TNIK | |
| SCHEMBL6528748 | 0.84 | RET (0.48) | ROCK2ROCK1TNIKUSP2ALDH1A1 | |
| SCHEMBL6529438 | 0.80 | CLK4 (0.43) | ROCK2ROCK1MAPKAPK2MEN1USP2 | |
| SCHEMBL6529343 | 0.80 | ABL1 (0.50) | ROCK2MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL6528938 | 0.80 | ROCK2 (0.51) | ROCK2MKNK1ROCK1MAPKAPK2TNIK | |
| SCHEMBL1013494 | 0.80 | ABL1 (0.60) | MKNK1MAPKAPK2TNIKCDC7PIK3CA | |
| SCHEMBL6528875 | 0.79 | ABL1 (0.49) | ROCK2MEN1ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005103036-A1 | PYRIMIDIN-4-YL-1H-INDAZOL-5YL-AMINES AS CHK1 KINASES INHIBITORS | BIOFOCUS DISCOVERY LTD (GB) | 2005-11-03 | — | — | WO | claimed |
| WO-2005103036-A1 | PYRIMIDIN-4-YL-1H-INDAZOL-5YL-AMINES AS CHK1 KINASES INHIBITORS | BIOFOCUS DISCOVERY LTD (GB) | 2005-11-03 | — | — | WO | disclosed |