Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 12/20 | 0.61 |
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28851008 | 0.87 | CHRNA7 (0.56) | CHRNA7APPMAPTSMN1; SMN2POLB | |
| SCHEMBL6530945 | 0.85 | KCNH3 (0.59) | CHRNA7APPMAPTTP53POLB | |
| SCHEMBL6529680 | 0.81 | KCNH3 (0.43) | CHRNA7APPMAPTSMN1; SMN2TP53 | |
| SCHEMBL6529816 | 0.81 | KCNH3 (0.43) | CHRNA7APPMAPTTP53POLB | |
| SCHEMBL6531533 | 0.81 | CA12 (0.45) | CHRNA7APPMAPTSMN1; SMN2TP53 | |
| SCHEMBL6531003 | 0.81 | CHRNA7 (0.63) | CHRNA7APPMAPTSMN1; SMN2 | |
| SCHEMBL28851466 | 0.80 | MAPT (0.63) | CHRNA7APPMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8298690 | 0.78 | APP (0.54) | CHRNA7APPMAPTSMN1; SMN2TP53 | |
| SCHEMBL6530404 | 0.78 | IDH2 (0.43) | CHRNA7MAPTTP53POLBMEN1 | |
| SCHEMBL6527570 | 0.78 | IDH2 (0.43) | CHRNA7MAPTTP53POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |