Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.63 |
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 8/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123529 | 0.85 | ABCG2 (0.58) | APPMAPTSMN1; SMN2ABCG2 | |
| SCHEMBL8298690 | 0.81 | APP (0.54) | CHRNA7APPMAPTSMN1; SMN2 | |
| SCHEMBL6529150 | 0.81 | CHRNA7 (0.61) | CHRNA7APPMAPTSMN1; SMN2 | |
| SCHEMBL2874930 | 0.79 | NFKB1 (0.65) | CHRNA7APPMAPTSMN1; SMN2 | |
| SCHEMBL28929970 | 0.77 | CHRNA7 (1.00) | CHRNA7APPMAPTSMN1; SMN2 | |
| SCHEMBL1594413 | 0.77 | ADORA2A (0.57) | CHRNA7APPMAPTSMN1; SMN2ABCG2 | |
| SCHEMBL1592702 | 0.75 | ABCG2 (0.57) | CHRNA7APPMAPTSMN1; SMN2ABCG2 | |
| SCHEMBL30933621 | 0.75 | TXN (0.46) | CHRNA7APPMAPTSMN1; SMN2RORC | |
| SCHEMBL6530084 | 0.75 | RORC (0.45) | CHRNA7RORCABCG2DHFR | |
| SCHEMBL6530078 | 0.75 | RORC (0.45) | CHRNA7RORCABCG2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |