Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651087 | 0.92 | LTB4R2 (0.34) | AGTR1LTB4R2 | |
| SCHEMBL648072 | 0.86 | AGTR1 (0.39) | ALDH1A1AGTR1POLBDRD2TBXA2R | |
| SCHEMBL651080 | 0.86 | MEN1 (0.38) | KMT2AMEN1ALDH1A1LMNAAGTR1 | |
| SCHEMBL648302 | 0.86 | AGTR1 (0.38) | AGTR1CMKLR1DRD2TBXA2RLTB4R2 | |
| SCHEMBL652332 | 0.86 | AGTR1 (0.36) | AGTR1CMKLR1DRD2TBXA2RLTB4R2 | |
| SCHEMBL650986 | 0.85 | AGTR1 (0.35) | AGTR1CMKLR1DRD2TBXA2RLTB4R2 | |
| SCHEMBL649495 | 0.85 | TLR8 (0.36) | AGTR1CMKLR1DRD2TBXA2R | |
| SCHEMBL652771 | 0.84 | TLR8 (0.36) | AGTR1CMKLR1DRD2TBXA2R | |
| SCHEMBL651303 | 0.84 | MC4R (0.37) | KMT2AAGTR1CMKLR1DRD2TBXA2R | |
| SCHEMBL650685 | 0.84 | MEN1 (0.38) | KMT2AMEN1ALDH1A1LMNAAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |