Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | USP8 | P40818 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378226 | 0.97 | GSK3B (0.55) | GSK3BCDK1CDK2STAT3PRKAB2 | |
| SCHEMBL1379072 | 0.92 | GSK3B (0.57) | GSK3BCDK1CDK2PIK3CAMAP2K4 | |
| SCHEMBL1378100 | 0.88 | GSK3B (0.53) | GSK3BCDK1CDK2PRKAB2PRKAG1 | |
| SCHEMBL1377458 | 0.87 | GSK3B (0.60) | GSK3BCDK1CDK2PIK3CGPIK3CD | |
| SCHEMBL1374941 | 0.87 | GSK3B (0.57) | GSK3BCDK1CDK2MAP2K4USP2 | |
| SCHEMBL1379009 | 0.84 | GSK3B (0.55) | GSK3BCDK1CDK2GAA | |
| SCHEMBL6528658 | 0.83 | GSK3B (0.54) | GSK3BCDK1CDK2MAP2K4CKS1B | |
| SCHEMBL2334200 | 0.83 | GSK3B (0.53) | GSK3BCDK1CDK2MAP2K4USP2 | |
| SCHEMBL6532777 | 0.82 | GSK3B (0.52) | GSK3BCDK1CDK2MAP2K4CKS1B | |
| SCHEMBL1379098 | 0.82 | GSK3B (0.59) | GSK3BCDK1CDK2CKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572200-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004062662-A1 | AMINOINDAZOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | WO | disclosed |