SCHEMBL6529561

SCHEMBL6529561

Sc1nc(-c2cnccn2)ns1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
PKM P14618 1/20 0.36
HTT P42858 1/20 0.35
RECQL P46063 1/20 0.35
KDM4E B2RXH2 2/20 0.35
GLA P06280 1/20 0.35
CYP1A2 P05177 1/20 0.34
NISCH Q9Y2I1 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CA P42336 1/20 0.33
PIK3CB P42338 1/20 0.33
PI4KA P42356 1/20 0.33
PIK3CG P48736 1/20 0.33
PI4KB Q9UBF8 1/20 0.33
METAP2 P50579 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9852299 0.78 ADORA2A (0.43) NPC1RAB9APKMHTTRECQL
SCHEMBL7016896 0.78 NPC1 (0.46) NPC1RAB9APKMHTTRECQL
SCHEMBL6529900 0.74 KDM4E (0.55) NPC1RAB9APKMHTTKDM4E
SCHEMBL4780009 0.73 NPC1 (0.46) NPC1RAB9APKMHTTRECQL
SCHEMBL25332902 0.70 TSHR (0.38) NPC1RAB9AHTTRECQLKDM4E
SCHEMBL6529431 0.70 PSMD14 (0.30)
SCHEMBL13978020 0.68 TP53 (0.44) NPC1RAB9APKMHTTRECQL
SCHEMBL20169517 0.67 KDM4E (0.44) NPC1RAB9APKMHTTRECQL
SCHEMBL78566 0.67 NISCH (0.50) NPC1RAB9APKMHTTRECQL
SCHEMBL29454745 0.67 NISCH (0.50) NPC1RAB9APKMHTTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005026139-A1 NEMATICIDAL DIFLUOROALKENES BAYER CROPSCIENCE AG (DE) 2005-03-24 WO disclosed
CN-1143962-A Triazole compound and processes for preparation thereof YUHAN CORP (KR) 1997-02-26 CN disclosed