Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716102 | 0.93 | MAPT (0.57) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4712174 | 0.86 | MAPT (0.51) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4789434 | 0.86 | ALDH1A1 (0.53) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4711774 | 0.82 | MAPT (0.51) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4715422 | 0.82 | MAPT (0.48) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4716291 | 0.80 | NOD2 (0.52) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4789540 | 0.78 | MAPT (0.49) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4714118 | 0.75 | MAPT (0.47) | MAPTTDP1ALDH1A1TSHRPOLB | |
| SCHEMBL4711636 | 0.74 | MEN1 (0.47) | MAPTALDH1A1POLBKDM4EL3MBTL1 | |
| SCHEMBL4716301 | 0.72 | MAPT (0.44) | MAPTTDP1ALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549648-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031188-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |