Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.66 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | TNKS | O95271 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28291729 | 0.87 | AKR1C3 (0.64) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1923197 | 0.85 | AKR1C3 (0.62) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL23216979 | 0.82 | AKR1C3 (0.58) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2209825 | 0.80 | TSHR (0.58) | KDM4EPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL312255 | 0.80 | AKR1C3 (1.00) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7703074 | 0.80 | TNKS (0.75) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8947940 | 0.79 | USP2 (0.58) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4634256 | 0.78 | HPGD (0.73) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1423180 | 0.76 | HPGD (0.67) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2436664 | 0.76 | HPGD (0.67) | KDM4EPOLBAKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6025211-A | — | — | None | — | — | JP | disclosed |
| JP-61238783-A | — | — | None | — | — | JP | disclosed |
| US-6965039-B2 | 7-carboxy-flavone derivatives preparation method and therapeutic use | NEGMA-LERADS (FR) | 2005-11-15 | — | — | US | disclosed |
| US-20040059136-A1 | 7-carboxy-flavone derivatives preparation method and therapeutic use | NEGMA-LERADS (FR) | 2004-03-25 | — | — | US | disclosed |
| EP-1212313-B1 | 7-CARBOXY-FLAVONE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE | NEGMA LERADS (FR) | 2003-05-28 | — | — | EP | disclosed |
| EP-1212313-A1 | 7-CARBOXY-FLAVONE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE | Negma-Lerads (FR) | 2002-06-12 | — | — | EP | disclosed |
| WO-2002028851-A1 | 7-CARBOXY-FLAVONE DERIVATIVES, PREPARATION METHOD AND THERAPEUTIC USE | NEGMA-LERADS (FR) | 2002-04-11 | — | — | WO | disclosed |
| JP-H0625211-A | FLAVONECARBOXYLIC ACID DERIVATIVE | MITSUBISHI KASEI CORP | 1994-02-01 | — | — | JP | disclosed |
| JP-S61238783-A | FLAVONE CARBOXAMIDE DERIVATIVE | HOKURIKU SEIYAKU CO LTD | 1986-10-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059136-A1 | 7-carboxy-flavone derivatives preparation method and therapeutic use | BCOR, CYP7B1, CYP21A2 | KDM4E 217/4885POLB 3199/4885AKR1C3 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.