Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 9/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 9/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.46 |
| ▸ | PRKCA | P17252 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.46 |
| ▸ | PRKCB | P05771 | 7/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906489 | 0.82 | JAK3 (0.82) | JAK1JAK3JAK2TYK2PRKCH | |
| SCHEMBL857150 | 0.67 | PRKCQ (0.72) | JAK1JAK3JAK2TYK2PRKCH | |
| SCHEMBL990717 | 0.67 | PRKCA (0.66) | JAK1JAK3JAK2TYK2PRKCH | |
| SCHEMBL24839369 | 0.67 | CDK7 (0.55) | CDK2CCNKCDK12CCNE1CCNT1 | |
| SCHEMBL21749386 | 0.66 | PRKCH (0.71) | JAK1JAK3PRKCHPRKCQPRKCD | |
| SCHEMBL29993829 | 0.65 | CDK7 (0.54) | CDK2CDK5CCNKCDK12CCNE1 | |
| SCHEMBL21026876 | 0.65 | CDK5 (0.69) | CDK2GSK3BCDK5CCNKCDK12 | |
| SCHEMBL517413 | 0.65 | CDK7 (0.54) | CDK2CDK5CCNKCDK12CCNE1 | |
| SCHEMBL20416024 | 0.65 | CDK7 (0.64) | CDK2CCNKCDK12CCNE1CCNT1 | |
| Sotrastaurin SCHEMBL26184899 | 0.64 | PRKCH (0.73) | JAK1JAK3PRKCHPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119274-A1 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2005-06-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119274-A1 | Indolylmaleimide derivatives | MYLK2, DGKK, LCK | JAK1 323/4885JAK3 410/4885JAK2 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.