Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509847 | 0.81 | TCF4 (0.52) | KDM4ENPC1RAB9ASMN1; SMN2HPSE | |
| SCHEMBL27829829 | 0.81 | ADORA2A (0.49) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL3663760 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL6713166 | 0.81 | NPC1 (0.43) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL6529784 | 0.80 | HPSE (0.61) | HPSECHEK2 | |
| SCHEMBL2178266 | 0.79 | NPC1 (0.88) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL29386825 | 0.79 | NPC1 (0.88) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL6511295 | 0.79 | MGAM (0.63) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL6509068 | 0.78 | CHEK2 (0.53) | KDM4EALDH1A1HPGDKMT2ANPC1 | |
| SCHEMBL24295036 | 0.78 | NPC1 (0.84) | KDM4EALDH1A1HPGDKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |