Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16703426 | 0.89 | GRM5 (0.40) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL10187775 | 0.87 | HDAC6 (0.44) | KDM4EKDM4AGABRG2GABRB3GABRA3 | |
| SCHEMBL19207174 | 0.69 | KDM4E (0.48) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL28338537 | 0.68 | KDM4E (0.53) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL1173966 | 0.66 | KDM4E (0.52) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL17427074 | 0.66 | KDM4E (0.56) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL30620596 | 0.66 | KDM4E (0.52) | DHODHKDM4EKDM6BKDM4AKDM5C | |
| Dipyridyl SCHEMBL2792069 | 0.66 | KDM4E (0.74) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| Dipyridyl SCHEMBL18601618 | 0.66 | KDM4E (0.74) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| Dipyridyl SCHEMBL30976994 | 0.66 | KDM4E (0.74) | KDM4EKDM6BKDM4AKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614234-B2 | Compounds as tyrosine kinase modulators | ALLERGAN, INC. (US) | 2013-12-24 | — | — | US | disclosed |
| EP-2473501-A1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | Allergan, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| US-20110053905-A1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | ALLERGAN, INC. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053905-A1 | COMPOUNDS AS TYROSINE KINASE MODULATORS | ABL1, ERBB2, LCK | DHODH 2718/4885KDM4E 1810/4885KDM6B 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.