SCHEMBL10187775

SCHEMBL10187775

O=C(NO)c1ccn(Oc2ccccc2)c1-c1ccccn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.44
HDAC8 Q9BY41 3/20 0.44
HDAC3 O15379 2/20 0.44
HDAC4 P56524 2/20 0.44
HDAC1 Q13547 2/20 0.44
HDAC7 Q8WUI4 2/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC10 Q969S8 2/20 0.44
HDAC11 Q96DB2 2/20 0.44
HDAC9 Q9UKV0 2/20 0.44
HDAC5 Q9UQL6 2/20 0.44
CYP3A4 P08684 3/20 0.40
CYP2C9 P11712 2/20 0.40
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA3 P34903 1/20 0.39
MITF O75030 1/20 0.38
CCR6 P51684 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6531022 0.87 DHODH (0.43) CYP3A4CYP2C9GABRG2GABRB3GABRA3
SCHEMBL16703426 0.84 GRM5 (0.40) CYP3A4CYP2C9GABRG2GABRB3GABRA3
SCHEMBL10187777 0.68 ALDH1A1 (0.40) HDAC8TDP1KDM4E
SCHEMBL30062391 0.67 HDAC6 (0.54) HDAC6HDAC8HDAC3HDAC4HDAC1
Dipyridyl SCHEMBL2792069 0.62 KDM4E (0.74) L3MBTL1TDP1ADORA3KDM4AKDM4B
Dipyridyl SCHEMBL18601618 0.62 KDM4E (0.74) L3MBTL1TDP1ADORA3KDM4AKDM4B
Dipyridyl SCHEMBL7773433 0.62 KDM4E (0.74) L3MBTL1TDP1ADORA3KDM4AKDM4B
Dipyridyl SCHEMBL30976994 0.62 KDM4E (0.74) L3MBTL1TDP1ADORA3KDM4AKDM4B
SCHEMBL5903774 0.61 HDAC1 (1.00) HDAC6HDAC8HDAC3HDAC4HDAC1
SCHEMBL13187688 0.60 HDAC6 (0.53) HDAC6HDAC8HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2473501-A1 COMPOUNDS AS TYROSINE KINASE MODULATORS Allergan, Inc. (US) 2012-07-11 EP disclosed