⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10367671 | 0.98 | CES2 (0.45) | — | |
| SCHEMBL11360228 | 0.80 | — | — | |
| SCHEMBL6519341 | 0.78 | — | — | |
| SCHEMBL28660261 | 0.77 | CES2 (0.45) | — | |
| SCHEMBL14387752 | 0.75 | CES2 (0.43) | — | |
| SCHEMBL6932749 | 0.74 | — | — | |
| SCHEMBL2789585 | 0.74 | CES2 (0.56) | — | |
| SCHEMBL13656481 | 0.74 | CES2 (0.56) | — | |
| SCHEMBL14798032 | 0.74 | CES2 (0.47) | — | |
| SCHEMBL9691076 | 0.74 | CES2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | claimed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | claimed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1992001667-A1 | RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-02-06 | — | — | WO | claimed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | claimed |
| EP-0186915-B1 | NOVEL ALLYLIC AMINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | claimed |
| US-4703058-A | β-methylene furanethanamines and use as anti-hypertensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-10-27 | — | — | US | claimed |
| EP-0186915-A2 | Novel allylic amines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-09 | — | — | EP | claimed |
| US-20050004225-A1 | Oxidoreductase inhibitors and methods of screening and using thereof | CITY OF HOPE | 2005-01-06 | — | — | US | disclosed |
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | disclosed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | disclosed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | disclosed |
| EP-0186915-B1 | NOVEL ALLYLIC AMINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| CN-1007247-B | PROCESS FOR THE PREPARATION OF NOVEL ALLYLIC AMINES | MERRELL DOW PHARMA (US) | 1990-03-21 | — | — | CN | disclosed |
| EP-0285356-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4703058-A | β-methylene furanethanamines and use as anti-hypertensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-10-27 | — | — | US | disclosed |
| US-4703058-A | β-methylene furanethanamines and use as anti-hypertensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0186915-A2 | Novel allylic amines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-09 | — | — | EP | disclosed |