Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408365 | 0.89 | DGAT1 (0.59) | DGAT1LMNAPOLBMAPTKDM4E | |
| SCHEMBL22324675 | 0.81 | DGAT1 (0.55) | DGAT1LMNAORAI1NPC1RAB9A | |
| SCHEMBL31470820 | 0.79 | LMNA (0.56) | DGAT1LMNAPOLBMAPTORAI1 | |
| SCHEMBL408901 | 0.79 | NPC1 (0.60) | DGAT1LMNAKDM4ENPC1RAB9A | |
| SCHEMBL8140350 | 0.79 | MAPT (0.71) | MAPTKDM4EHPGDTP53ORAI1 | |
| SCHEMBL5608275 | 0.79 | DGAT1 (0.53) | DGAT1LMNANPC1RAB9A | |
| SCHEMBL24303811 | 0.78 | CA12 (0.56) | DGAT1LMNAMAPTKDM4ETP53 | |
| SCHEMBL408172 | 0.78 | NPSR1 (0.60) | DGAT1POLBMAPTNPC1RAB9A | |
| SCHEMBL22324674 | 0.77 | DGAT1 (0.65) | DGAT1 | |
| SCHEMBL4298343 | 0.77 | DGAT1 (0.67) | DGAT1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958339-B2 | Pyrazole derivative | ASTELLAS PHARMA INC. (JP) | 2005-10-25 | — | — | US | disclosed |