Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10136521 | 0.87 | NCEH1 (0.54) | ALOX5NCEH1ALDH1A1KDM4EDHFR | |
| SCHEMBL15750908 | 0.84 | ALOX5 (0.46) | ALOX5NCEH1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL809207 | 0.81 | ALOX5 (0.44) | ALOX5NCEH1ALDH1A1KDM4EDHFR | |
| SCHEMBL808973 | 0.81 | ALOX5 (0.44) | ALOX5NCEH1ALDH1A1KDM4EDHFR | |
| Iodide SCHEMBL25290235 | 0.80 | MAPT (0.55) | NCEH1ALDH1A1KDM4EMAPK1HPGD | |
| SCHEMBL15750787 | 0.79 | ALOX5 (0.45) | ALOX5NCEH1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL19036424 | 0.79 | ALOX5 (0.40) | ALOX5ALDH1A1KDM4EDHFRMAPK1 | |
| SCHEMBL1807920 | 0.76 | NCEH1 (0.53) | ALOX5NCEH1ALDH1A1KDM4EDHFR | |
| SCHEMBL5950064 | 0.76 | L3MBTL1 (0.45) | ALOX5NCEH1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL2045141 | 0.75 | ALOX5 (0.65) | ALOX5ALDH1A1KDM4EDHFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575951-A1 | HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY | Affinium Pharmaceuticals, Inc. (CA) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004052890-A1 | HETEROCYCLIC COMPOUNDS, METHODS OF MAKING THEM AND THEIR USE IN THERAPY | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-06-24 | — | — | WO | disclosed |