Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532745 | 0.70 | CCNE2 (0.41) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL2196669 | 0.69 | CDC7 (0.46) | ADORA2AADORA3MEN1KMT2AKDM4E | |
| SCHEMBL4314653 | 0.68 | KDM4E (0.47) | ADORA2AADORA3MEN1KMT2AKDM4E | |
| SCHEMBL23365044 | 0.67 | ADORA2A (0.50) | ADORA2AADORA3MEN1KMT2AKDM4E | |
| SCHEMBL6533212 | 0.67 | PARP1 (0.44) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| SCHEMBL6533209 | 0.67 | PARP1 (0.41) | ADORA2AADORA3MEN1KMT2AKDM4E | |
| SCHEMBL4341036 | 0.65 | KDM4E (0.50) | ADORA2AADORA3MEN1KMT2AKDM4E | |
| SCHEMBL2454771 | 0.65 | KMT2A (0.41) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL1385872 | 0.65 | IKBKB (0.67) | KMT2AKDM4EMAPTNPC1NPSR1 | |
| SCHEMBL2454769 | 0.65 | KMT2A (0.41) | MEN1KMT2AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |