Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314650 | 0.70 | KDM4E (0.43) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL6532748 | 0.70 | ADORA2A (0.42) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4341035 | 0.67 | KDM4E (0.44) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL1385872 | 0.65 | IKBKB (0.67) | KDM4EMAPTKMT2ANPC1NPSR1 | |
| SCHEMBL6532742 | 0.64 | NR3C1 (0.44) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL5554748 | 0.62 | IKBKB (0.58) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL30174203 | 0.62 | ERCC1 (0.46) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL6533212 | 0.62 | PARP1 (0.44) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4092063 | 0.62 | KIF11 (0.51) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL15109937 | 0.62 | KDM4E (0.44) | KDM4EALDH1A1GAAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |