Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 19/20 | 0.52 |
| ▸ | GABRD | O14764 | 19/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 19/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 19/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 19/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 19/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 19/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 19/20 | 0.52 |
| ▸ | GABRE | P78334 | 19/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 19/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 19/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 19/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 19/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344371 | 0.86 | GABRP (0.69) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8542883 | 0.78 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6353825 | 0.77 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6343077 | 0.76 | GABRP (0.66) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6340105 | 0.75 | GABRP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6353305 | 0.75 | GABRP (0.70) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6342979 | 0.75 | GABRA2 (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6343979 | 0.74 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6345914 | 0.74 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6346313 | 0.72 | GABRA2 (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005023773-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED ARYL PYRAZOLES | PFIZER LIMITED (GB) | 2005-03-17 | — | — | WO | disclosed |