Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533749 | 0.83 | HDAC1 (0.31) | HDAC1HDAC4 | |
| SCHEMBL28334169 | 0.77 | TSHR (0.45) | TSHRSMN1; SMN2TDP1ALDH1A1HSD17B10 | |
| SCHEMBL28336371 | 0.74 | SMN1; SMN2 (0.42) | TSHRSMN1; SMN2TDP1ALDH1A1HSD17B10 | |
| SCHEMBL10918146 | 0.74 | TSHR (0.42) | TSHRSMN1; SMN2TDP1ALDH1A1HSD17B10 | |
| Sulfuric Acid SCHEMBL4306444 | 0.74 | KMT2A (0.31) | — | |
| Hydrochloric Acid SCHEMBL8754758 | 0.73 | KDM4E (0.52) | ALDH1A1HDAC1HDAC4 | |
| SCHEMBL10786211 | 0.72 | LMNA (0.54) | TSHRSMN1; SMN2ALDH1A1LMNACYP2D6 | |
| SCHEMBL14387378 | 0.72 | KMT2A (0.49) | TSHRALDH1A1NAPRTLMNACYP2D6 | |
| SCHEMBL15174678 | 0.71 | HDAC1 (0.42) | TSHRLMNAHDAC1HDAC4 | |
| Fluoride Ion SCHEMBL5148077 | 0.71 | KMT2A (0.47) | TSHRALDH1A1NAPRTLMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |