Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 2/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534179 | 1.00 | NR2E1 (0.55) | NR2E1LMNAHPGDSMN1; SMN2ACP1 | |
| Hydrochloric Acid SCHEMBL6534396 | 0.99 | NR2E1 (0.53) | NR2E1LMNAHPGDSMN1; SMN2ACP1 | |
| Hydrochloric Acid SCHEMBL6534393 | 0.99 | NR2E1 (0.53) | NR2E1LMNAHPGDSMN1; SMN2ACP1 | |
| SCHEMBL6534248 | 0.82 | CYP2D6 (0.62) | NR2E1LMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6534244 | 0.82 | CYP2D6 (0.62) | NR2E1LMNAHPGDSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6534372 | 0.81 | LMNA (0.50) | LMNAHPGDSMN1; SMN2ACP1MAPT | |
| Hydrochloric Acid SCHEMBL6534370 | 0.81 | LMNA (0.50) | LMNAHPGDSMN1; SMN2ACP1MAPT | |
| Hydrochloric Acid SCHEMBL6534648 | 0.79 | KMT2A (0.53) | LMNAHPGDSMN1; SMN2ACP1 | |
| Hydrochloric Acid SCHEMBL6534649 | 0.79 | KMT2A (0.53) | LMNAHPGDSMN1; SMN2ACP1 | |
| SCHEMBL6534362 | 0.78 | KMT2A (0.56) | LMNAACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | claimed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | claimed |
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |