SCHEMBL6534244

SCHEMBL6534244

CC(C)NCC(O)COc1cc(-c2ccccc2)nc2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 5/20 0.62
ADRB2 P07550 6/20 0.59
ADRB1 P08588 6/20 0.59
ADRB3 P13945 5/20 0.59
SIGMAR1 Q99720 4/20 0.59
CYP1A2 P05177 3/20 0.59
SLC6A4 P31645 3/20 0.59
HTR2B P41595 3/20 0.59
NR2E1 Q9Y466 3/20 0.59
ALDH1A1 P00352 3/20 0.59
HTR2A P28223 3/20 0.59
HTR2C P28335 3/20 0.59
HTR6 P50406 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
LMNA P02545 3/20 0.59
SCN1A P35498 2/20 0.59
SLC10A1 Q14973 2/20 0.59
SCN2A Q99250 2/20 0.59
SCN3A Q9NY46 2/20 0.59
HTR1A P08908 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6534248 1.00 CYP2D6 (0.62) CYP2D6ADRB2ADRB1ADRB3SIGMAR1
SCHEMBL6534438 0.88 CYP2D6 (0.61) CYP2D6ADRB2ADRB1ADRB3SIGMAR1
SCHEMBL6534435 0.88 CYP2D6 (0.61) CYP2D6ADRB2ADRB1ADRB3SIGMAR1
Hydrochloric Acid SCHEMBL6534421 0.88 CYP2D6 (0.60) CYP2D6ADRB2ADRB1ADRB3SIGMAR1
Hydrochloric Acid SCHEMBL6534418 0.88 CYP2D6 (0.60) CYP2D6ADRB2ADRB1ADRB3SIGMAR1
Hydrochloric Acid SCHEMBL6534370 0.85 LMNA (0.50) CYP2D6ALDH1A1SMN1; SMN2LMNAHPGD
Hydrochloric Acid SCHEMBL6534372 0.85 LMNA (0.50) CYP2D6ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL6534362 0.82 KMT2A (0.56) ADRB2ADRB1LMNAHTR1AABCB1
SCHEMBL6534512 0.82 KMT2A (0.59) ADRB2ADRB1LMNAHTR1AABCB1
SCHEMBL6534517 0.82 KMT2A (0.59) ADRB2ADRB1LMNAHTR1AABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1088818-B1 Quinolin-4-yl derivatives HOFFMANN LA ROCHE (CH) 2004-11-03 EP claimed
US-6440995-B1 NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS HOFFMAN-LA ROCHE INC. 2002-08-27 US claimed
EP-1088818-A1 Quinolin-4-yl derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-04-04 EP claimed
EP-1088818-B1 Quinolin-4-yl derivatives HOFFMANN LA ROCHE (CH) 2004-11-03 EP disclosed
US-6440995-B1 NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS HOFFMAN-LA ROCHE INC. 2002-08-27 US disclosed
EP-1088818-A1 Quinolin-4-yl derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-04-04 EP disclosed