Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193346 | 1.00 | FAAH (0.53) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL17803291 | 0.92 | MTNR1A (0.49) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL1192966 | 0.85 | FAAH (0.46) | FAAHP2RX7MTNR1AMTNR1B | |
| SCHEMBL30599788 | 0.85 | FAAH (0.46) | FAAHP2RX7MTNR1AMTNR1B | |
| SCHEMBL367535 | 0.84 | FAAH (0.53) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL6427539 | 0.84 | FAAH (0.53) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL5608206 | 0.84 | FAAH (0.53) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL406043 | 0.82 | MTNR1A (0.57) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| SCHEMBL346421 | 0.82 | PLAU (0.52) | FAAHP2RX7MTNR1AMTNR1BPLAU | |
| Hydrochloric Acid SCHEMBL9266537 | 0.82 | ANPEP (0.53) | FAAHP2RX7MTNR1AMTNR1BPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |