Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534354 | 0.86 | MAPT (0.45) | MAPTPOLBACACAPDE10AMEN1 | |
| SCHEMBL6534203 | 0.85 | PDE10A (0.54) | TP53MAPTKDM4ELMNAHTT | |
| SCHEMBL6534631 | 0.80 | ALDH1A1 (0.50) | MAPTKDM4ELMNAMEN1HPGD | |
| SCHEMBL28118267 | 0.77 | KDM4E (0.43) | TP53MAPTKDM4ELMNAHTT | |
| SCHEMBL28621639 | 0.76 | KDM4E (0.47) | TP53MAPTKDM4ELMNAHTT | |
| SCHEMBL6534237 | 0.75 | MAPK1 (0.50) | MAPTKDM4EHTTPOLBACACA | |
| SCHEMBL6534271 | 0.75 | KDM4E (0.54) | MAPTKDM4ELMNAHTTACACA | |
| SCHEMBL18698086 | 0.74 | KDM4E (0.52) | TP53MAPTKDM4ELMNAHTT | |
| SCHEMBL28115476 | 0.73 | POLB (0.57) | TP53MAPTKDM4ELMNAHTT | |
| SCHEMBL3617718 | 0.71 | KDM4E (0.53) | TP53MAPTKDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | claimed |