Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534280 | 1.00 | KDM4E (0.66) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL14279421 | 0.79 | KDM4E (1.00) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL4810314 | 0.79 | KDM4E (1.00) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL6492672 | 0.79 | KDM4E (0.66) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL6492668 | 0.79 | KDM4E (0.66) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL18740730 | 0.79 | MAOA (0.45) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL31428642 | 0.79 | MAOA (0.45) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL4387472 | 0.79 | MAOA (0.45) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL10662516 | 0.77 | KDM4E (0.67) | KDM4ERAB9AMAPTL3MBTL1POLB | |
| SCHEMBL10662511 | 0.77 | KDM4E (0.67) | KDM4ERAB9AMAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1181059-C | Quinoline-4-base deviative I | - | 2004-12-22 | — | — | CN | disclosed |
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| CN-1290698-A | Quinoline-4-base deviative I | HOFFMANN LA ROCHE (CH) | 2001-04-11 | — | — | CN | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |
| US-4304841-A | DISULFIDE COMPOUND TO LOWER SENSITIVITY TO OXYGEN | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-12-08 | — | — | US | disclosed |
| US-4272609-A | 2-ALKENYL QUINOLINE PHOTOINITIATOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-06-09 | — | — | US | disclosed |