Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACA | Q13085 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534192 | 0.89 | ACACA (0.58) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL6534318 | 0.82 | MAPT (0.71) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL29636789 | 0.82 | MAPT (0.71) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL6001926 | 0.82 | ACACA (0.60) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL6534274 | 0.82 | MEN1 (0.53) | ACACAHTTMAPTDHODHKMT2A | |
| SCHEMBL6534253 | 0.81 | TP53 (0.47) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL5822925 | 0.81 | ACACA (0.49) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL9788752 | 0.80 | DHODH (0.69) | HPGDLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3909868 | 0.79 | HSP90AA1 (0.55) | ACACAHPGDLMNASMN1; SMN2KDM4E | |
| SCHEMBL30592743 | 0.78 | DHODH (0.58) | ACACAHPGDLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |