Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42477 | 0.84 | DHODH (0.81) | DHODHKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29788461 | 0.84 | DHODH (0.81) | DHODHKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL116026 | 0.82 | KDM4E (0.85) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL28576456 | 0.81 | DHODH (0.69) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL2467110 | 0.81 | DHODH (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL29536364 | 0.81 | DHODH (1.00) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL117357 | 0.80 | DHODH (0.71) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL6534368 | 0.80 | ACACA (0.60) | DHODHKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2291034 | 0.80 | DHODH (0.80) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL29788462 | 0.80 | DHODH (0.80) | DHODHKDM4ELMNASMN1; SMN2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032597-A | Antitumor | DU PONT MERCK PHARMACEUTICAL (US) | 1991-07-16 | — | — | US | disclosed |
| US-4680299-A | ANTITUMOR AGENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0133244-A2 | Phenylquinolinecarboxylic acids and derivatives as antitumor agents | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-02-20 | — | — | EP | disclosed |